Forge of Empires FOE was published in as the newest strategy online game by InnoGames and has since been one of the most successful browser-based games available. InnoGames, known as a publisher of high quality titles such as the strategy game Tribal Wars and the Greek empire game Grepolis , is combining strategic game-play in an empire builder with excellent visual appeal.
But excellent quality, however, is not the only thing unique about Forge of Empires: like all strategy games by InnoGames , a huge community has developed, bringing players from all over the world together. The newest Forge of Empires FOE trailer shows some of the best characteristics of the strategy online game and gives you a feel for the world FOE plays in. Following a few settlers through the ages into medieval times, it depicts the conquest of the world by your thriving realm.
Whether you play the strategy game as a peaceful ruler or evil emperor ambushing neighboring settlements is up to you to decide. This majestic online game lets you decide how powerful your Empire will become — play FOE now. In the beginning you settle in the Stone Age with only a few huts. Then, with the right strategy you develop your capital and expand your online empire by conquering nearby provinces.
The results will be shared with the local community that enabled the research, and also to the international fora. Jensen, G. Preterm infants receiving human milk have lower incidence of sepsis and NEC than those fed a bovine milk-based preterm formula.
The aim of this study is to evaluate whether the supplementation of human milk-based, as compared with bovine-based, nutrient fortifier reduces the prevalence of NEC, sepsis and mortality in ELGA infants exclusively fed with human milk.
The primary outcome is a composite of NEC, sepsis or death. Infants are characterised with comprehensive clinical and nutritional data collected prospectively from birth until hospital discharge. Stool, urine, blood and breast milk samples are collected for analyses in order to study underlying mechanisms.
A follow-up focusing on neurological development and growth will be performed at 2 and 5. Health economic analyses will be made. Results will be presented at scientific meetings and published in peer-reviewed publications. Trial registration number The study was registered with ClinicalTrials.
Hui, L. Background The COVID pandemic has resulted in a range of unprecedented disruptions to maternity care with documented impacts on perinatal outcomes such as stillbirth and preterm birth. Metropolitan Melbourne has endured one of the longest and most stringent lockdowns in globally. This paper presents the protocol for a multicentre study to monitor perinatal outcomes in Melbourne, Australia, during the COVID pandemic. Perinatal outcomes will include weekly rates of total births, stillbirths, preterm births, neonatal intensive care admissions, low Apgar scores and fetal growth restriction.
Maternal outcomes will include weekly rates of: induced labour, caesarean section, births before arrival to hospital, postpartum haemorrhage, length of stay, general anaesthesia for caesarean birth, influenza and COVID vaccination status, and gestation at first antenatal visit. A prepandemic median for all outcomes will be calculated for the period of January to March Additional statistical analyses such as regression, time series and survival analyses will be performed for an in-depth examination of maternal and perinatal outcomes of interests.
Cecilia G. Carvalhaes Helio S. Sader Jennifer M. Streit Mariana Castanheira Rodrigo E. Dina Zheng Phillip J. Bergen Cornelia B. Landersdorfer Elizabeth B. Helena C. Sipsas, Athanasios Tsakris. Narayan, Rakesh K. Jha, Himanshu N. Singh, Pranav Prasoon, Sada N. Pandey, Kamla Kant. Toxoplasmosis reactivation after allogenic hematopoietic cell transplantation allo-HCT is still an issue of concern [1]. Prophylaxis with co-trimoxazole is generally the mainstay preventive measure in high risk patients also including P.
Molecular techniques for Toxoplasma detection in blood samples, initially used for the early diagnosis of disseminated toxoplasmosis [3, 4], are being postulated as potential monitoring tools for preemptive strategies in this population, since blood DNAemia can precede end-organ toxoplasmosis by weeks [5], and monitoring of toxoplasma DNAemia have been recommended in high risk allo-HCT recipients not receiving toxoplasma prophylaxis in the early post-allo-HCT period [6, 7].
A year-old man with a history of travel to India had 3 months of upper back pain and 2 weeks of dry cough and subjective fevers that did not improve with empirical azithromycin. Chest CT showed a dense consolidation in the left lower lobe; MRI showed a paraspinal mass with extensive contrast enhancement in the lower thoracic vertebral bodies and relative sparing of the disks.
What is the diagnosis and what would you do next? During the earlier years of the development of the modern science of bacteriology, the hunt for harmful microbes was a popular laboratory pastime. The readily secured evidence of the widespread distribution of germs—perhaps it should be designated the omnipresence of bacteria—at first disturbed the peace of mind of many persons who now saw the possibilities of disease transmission awaiting them at every turn.
Presently, however, it became clearer that not all micro-organisms are baneful and that some are at least relatively innocuous; while the varied protective devices of the human organism against the microscopic invaders were being discovered in rapid succession, thus bringing the sense of relief that comes from the contemplation of our factors of safety.
To the Editor The recent study evaluating 7- vs day duration of therapy for afebrile men with urinary tract infection UTI advanced understanding of treatment for a common ambulatory infection. However, a basic principle of clinical research is appropriate matching of research questions with study designs that evaluate those questions. The study design to address this question would use a superiority hypothesis with randomization after initial symptom recovery.
This trial design addresses a different research question and raises challenges in scientific validity as well as differing trial conclusions. To the Editor We have some concerns about the recent study by Dr Drekonja and colleagues. First, UK and European guidelines have recommended 7-day treatment for afebrile men with UTI since , making it unlikely that the findings of this trial will change clinical practice in these countries.
Second, we were surprised at the inclusion of ciprofloxacin, given warnings from the US Food and Drug Administration and other organizations. Ciprofloxacin warnings and increasing use of other antibiotics eg, nitrofurantoin could have prompted this trial team and its steering committee to consider whether ciprofloxacin remained an appropriate and relevant choice of antibiotic.
To the Editor I have several concerns about the conclusion of a recent article that 7 days of antibiotic treatment in afebrile men with UTI was noninferior to 14 days. First, diagnosis of uncomplicated UTI in men is not always straightforward. However, some patients may have prostatic hypertrophy or an indwelling urinary catheter, which may cause symptoms similar to a UTI.
Second, investigating antibiotic treatment for UTI requires a high level of diagnostic accuracy, including the identification of the urinary pathogen and estimation of levels of pretreatment bacteriuria. Antibiotic sensitivity and bacteriuria levels could confound the relationship between treatment duration and resolution of symptoms. Third, antibiotic susceptibilities may vary depending on variables such as region because of different approaches to antimicrobial stewardship and uropathogen strain.
Fourth, I am concerned about the inclusion of 2 different antibiotics in the study. Uropathogenic Escherichia coli commonly exhibits lower antibiotic susceptibility to trimethoprim than do fluoroquinolones, which may result in poorer outcomes in the group treated with trimethoprim-sulfamethoxazole.
In Reply We appreciate the opportunity to respond to the issues raised in these Letters to the Editor about our study. They also call for investigators, sponsors, and scientific and ethical review boards to evaluate the use of noninferiority trials.
The Veterans Affairs reviewers recommended this change, noting that the bulk of the published studies of antimicrobial duration have been noninferiority trials. Because antimicrobial therapy is superior to no antimicrobial therapy for UTI, we strongly doubt that 7 and 14 days of antimicrobial therapy yielded similar outcomes because neither duration is effective. The approach allows students to attend school and may reduce other negative consequences of isolating at home, according to the investigators.
In a trial conducted during the COVID pandemic, virtual care with remote automated monitoring RAM increased drug error detection and correction and decreased pain among patients discharged home after nonelective surgery.
However, virtual care did not affect days alive at home following discharge compared with standard care. Poor practices at a third-party health care company hired in to provide routine workplace vaccinations in 3 states led to vaccine-associated adverse events, an investigation by the CDC and state public health authorities found. Nonalcoholic fatty liver disease NAFLD , the hepatic manifestation of metabolic syndrome, is the leading cause of liver disease worldwide.
In liver disease, the progression of fibrosis to cirrhosis and the development of decompensation, including hepatic encephalopathy, variceal hemorrhage, and ascites, occur over decades and randomized clinical trials are not well-equipped to evaluate these outcomes. Thus, evaluation of potentially effective therapies to prevent liver-related events requires novel study designs.
This cohort study investigates the association between bariatric surgery and incident major adverse liver outcomes and major adverse cardiovascular events in patients with obesity and biopsy-proven fibrotic NASH without cirrhosis.
It is also apparent that breakthrough infections in fully vaccinated people can sometimes be serious. Furthermore, multiple reports have documented that if fully vaccinated individuals do become infected, their viral loads may be as high as the levels seen in unvaccinated individuals.
Can anyone help me? Just wanted to add to the list of resources my tutorial series "SimCity Guide to Custom Creations" for a breakdown of custom building design. Thanks Benji. I was thinking I should add that to this page. I'll do that now. Thanks for the heads up on the Budget Map mod link being dead. Looks like the mod was taken down. Trying to figure out why.
Ronnie, any mod that is zipped is a PC exec file and won't work on a Mac, just look for mods that aren't zipped. Will modding create any problems with original simcity application like unable to update when updates are released or something like that???
I haven't heard of any issues with game updates not working after applying a mod, so I think it's safe. The biggest problem I hear about is when people use off-line only mods in online games, it will cause crashes and rollbacks. Skyestorme posted a city he did in one of his video series. Hopefully Skye will have it up and running soon. Can someone upload Skye's Regional Freeway Mod on another server and pass the link? I need this mod. This probably isn't the most recent, but it's the one I've been using.
Can someone send me the skye pack mod? I can't download it. Thankyou guys. The information on this particular page is strictly for the PC game. There are ways to hack the mobile game, but you won't get that information here. I'm against hacking the mobile game because it messes up the trade communities and legitimacy of the mayor contests and such.
Can someone upload Skye's Regional Freeway Mod on another server please? Is this link to the Skyes Mod Pack still on? Because it links to a fishy website, apparently.
Is it still safe in ? Is it still working in ? Mod Installation Guide. Mods: Where to find them and how to install them What is a mod? A mod is a small file with a. It might be something simple like different looking police cars or something more significant like the ability to add additional entrances to your city. Step 1. Find a mod from Simtropolis A , Skyestorme. When you find what you want, click on the green "Download" Button Note: Before attempting to download a mod, make sure you've signed in to simtropolis.
Downloading may not work if you're not signed in. They're both free.
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